91³Ô¹Ï

Abstract

Phosphorus-31 & fluorine-19 NMR spectroscopies are analytical techniques based on the detection of 31P & 19F nucleus. Because of high natural isotopic abundance and a relatively high magnetogyric ratio, these nucleuses are highly responsive to NMR measurements and hence are being used as one of the more routine NMR techniques. The 31P & 19F nucleus also have a spin of ½, making spectra relatively easy to interpret. Phosphorus & fluorine both are commonly found in drugs, biological samples & prodrugs. Current poster reviews the few 31P & 19F applications which can be widely utilized in modern research. As a first example of 19F -NMR spectroscopy, its application to the identification of metabolites of fluorine containing drugs is discussed while 2 nd example of 19F NMR presents the methodology of using this nucleus to study the structure & dynamics of DNA-carcinogen adducts. As a first example of 31P-NMR spectroscopy, its usefulness to assign structures of phosphorus-containing prodrugs is discussed because these signals are well resolved and often occur at characteristic frequencies. 2 nd example of 31P-NMR spectroscopy will display the use of 31P-NMR experiment for metabolite profiling of lipophilic compounds in human serum.

Biography

Abhishek Gupta is Master?s in Biochemistry & Instrumentation and currently pursuing his doctoral thesis from Indian Institute of Technology (IIT), Delhi, India. He is the Senior Research Scientist of Daiichi Sankyo India Pharma Private Limited in India, a subsidiary of Daiichi Sankyo-Japan, a premier drug discovery research based organization. He is having more than 12 years of versatile experience in the field of NMR spectroscopy & published more than 6 papers in reputed journals.