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Abstract

Polymeric nanoparticles (NPs) combined with lipids can have profound effects on treatment efficacy in patients with neurological disorders such as Alzheimerâ�?�?s Disease (AD). We developed polyacrylamide (PAAM)-cardiolipin (CL)poly(lactide-co-glycolide) (PLGA) NPs grafted with surface 83-14 Monoclonal Antibody (MAb) to carry Rosmarinic Acid (RA) and Curcumin (CUR). This drug delivery system was used to cross the Blood-Brain Barrier (BBB) and enhance the viability of SK-N-MC cells insulted with �?²-Amyloid (A�?²) deposits. Experimental evidence revealed that an increase in the concentration of 83-14 MAb enhanced the permeability coefficient of RA and CUR using the nanocarriers. The levels of phosphorylated p38 and phosphorylated Ï�?-protein at serine 202 in degenerated SK-N-MC cells were in the order: A�?²>(A�?²+RA-CUR)>(A�?²+83-14 MAb-RA-CUR-PAAM-PLGA NPs)>(A�?²+83-14 MAb-RA-CUR-PAAM-CL-PLGA NPs)â�?�?control. The viability of SK-N-MC cells reduced with time and CL in 83-14 MAb-RA-CUR-PAAM-CL-PLGA NPs advantaged A�?²-targeted delivery of RA-CUR. These results evidenced that the current 83-14 MAb-RA-CUR-PAAM-CL-PLGA NPs can be a promising pharmacotherapy to permeate the BBB and reduce the fibrillar A�?²-induced neurotoxicity.

Biography

Yung-Chih Kuo is a Professor at National Chung Cheng University, Taiwan. His research interests are focused on biomaterials, nanomedicine, tissue engineering, blood-brain barrier, cancer therapy, nerve regeneration, spinal cord injury and stroke treatment and Alzheimer’s and Parkinson’s disease therapy. He has authored over 140 SCI journal papers. He is a Fellow of Royal Society of Chemistry, UK and an Honor Member of Phi Tau Phi Society. He has also won Prof. Yen-Ping Shih Award in 2017; Best Paper Award in 2016 and 2008; Prof. Tsai-Teh Lai Award in 2015; Special and Talented Scholar Award in 2013 and Outstanding Research Award in 2013.
Email:chmyck@ccu.edu.tw