91勛圖

Abstract

Malaria is an important parasitic disease that consider as a threat of public health in worldwide. Plasmodium vivax causes malaria infection mainly in Asia, South America and Oceania. In Iran, as member of east Mediterranean region office (EMRO), Plasmodium vivax and Plasmodium falciparum are responsible of malaria that occur mainly in south and southeast of the country. This area has common borders with Pakistan and Afghanistan. Plasmodium vivax accounts as agent of more than 90% of malaria cases in Iran. The access to enough information about population structure of Plasmodium vivax is necessary for developing malaria vaccine and epidemiological studies. The present study was conducted to determine population genetic diversity of Plasmodium vivax in southeast of Iran. Blood was taken from symptomatic malaria patients. The nested PCR were performed to amplify the two merozoite antigens of Plasmodium vivax. The products of PCR were sequenced. The MEGA 5 and DNASP software were used for the genetic analysis. The nucleotide sequences were deposited in world gene bank. The findings of present study showed genetic diversity in Plasmodium vivax population in the hypo-endemic area for malaria in Iran. aliehsan2001@yahoo.com

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