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Abstract

Alzheimer?s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment. Codonopsis lanceolata has been employed clinically for lung inflammatory diseases such as asthma, tonsillitis, and pharyngitis. The present study was undertaken to evaluate the effect of fermented C. lanceolata (300, 500 and 800 mg/kg) on learning and memory impairment induced by scopolamine using the Morris water maze test and passive avoidance test. The results of Morris water maze test and passive avoidance test that administration of fermented C. lanceolata (800 mg/kg) led to improve memory. The neuroprotective effect of fermented C. lanceolata against the cytotoxicity induced by glutamate in HT22 cell. Fermented C. lanceolata also showed neuroprotective effect at the concentration of 500 μg/ml. These results indicate that effect of fermented C.lanceolata improved memory deficit in scopolamine induced mouse and may suggest alternative agent for treatment of AD.

Biography

Woo Seok Choi attends the department of Medical Biomaterials Engineering in Kangwon National University, Korea and he will graduate from in 2014. Now he is a student in Food & Bioprocess Engineering Lab in Kangwon National University and he applies for admission to the master?s course in Kangwon National University.