91吃瓜

Abstract

Mass spectrometry (MS) has long been a cornerstone of bioanalytical science, enabling the identification and quantification of molecules within complex biological systems. Recent advancements in MS techniques—such as ambient ionization, high-resolution mass spectrometry (HRMS), and ion mobility spectrometry (IMS)—have expanded its capabilities, addressing challenges posed by the heterogeneity, dynamic range, and structural complexity of biological samples. This article explores how these emerging MS technologies are revolutionizing the analysis of intricate bioanalytical systems, including proteomics, metabolomics, and lipidomics. By improving sensitivity, throughput, and specificity, these innovations facilitate deeper insights into disease mechanisms, drug development, and personalized medicine. The discussion evaluates their practical impact, current limitations, and future potential, emphasizing their role in overcoming longstanding bioanalytical hurdles.