Nanostructured Lipid Carriers for Enhanced Oral Delivery of Poorly Soluble Drugs: Formulation, Characterization, and Pharmacokinetic Study
Received Date: Jan 01, 2024 / Published Date: Jan 29, 2024
Abstract
The oral bioavailability of poorly water-soluble drugs remains a significant barrier in modern drug development. Nanostructured lipid carriers (NLCs) have emerged as an effective platform to enhance drug solubility, stability, and gastrointestinal absorption. This study presents the development and evaluation of curcumin-loaded NLCs prepared via hot homogenization followed by ultrasonication. The formulation was characterized for particle size, zeta potential, encapsulation efficiency, in vitro release, and pharmacokinetics in Wistar rats. The results showed that the NLCs significantly improved the solubility and systemic availability of curcumin compared to pure drug suspension, offering a potential approach for the oral delivery of lipophilic drugs.
Citation: Priya SM (2025) Nanostructured Lipid Carriers for Enhanced Oral Deliveryof Poorly Soluble Drugs: Formulation, Characterization, and PharmacokineticStudy. J Mol Pharm Org Process Res 13: 273.
Copyright: 穢 2025 Priya SM. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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