Green Synthesis and Optimization of 2-Phenylbenzimidazole via Microwave-Assisted Cyclocondensation: A Sustainable Approach in Organic Process Research
Received Date: Jan 01, 2024 / Published Date: Jan 29, 2024
Abstract
The development of sustainable synthetic methodologies is a key challenge in modern organic process research. This study describes a green and efficient microwave-assisted synthesis of 2-phenylbenzimidazole via cyclocondensation of o-phenylenediamine and benzaldehyde in aqueous ethanol without the use of catalysts. Reaction parameters were optimized using a factorial design to maximize yield and purity. Compared to conventional thermal methods, microwave irradiation significantly reduced reaction time and energy input, offering an eco-friendly and scalable process. The synthesized compound was characterized by FTIR, NMR, and elemental analysis. This method aligns with the principles of green chemistry and presents potential for industrial application.
Citation: Javier MR (2025) Green Synthesis and Optimization of2-Phenylbenzimidazole via Microwave-Assisted Cyclocondensation: A SustainableApproach in Organic Process Research. J Mol Pharm Org Process Res 13: 272.
Copyright: 漏 2025 Javier MR. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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