91吃瓜

Abstract

N-Substituted pyrroles are valuable intermediates in the synthesis of pharmaceuticals, agrochemicals, and materials. Traditional batch methods for their synthesis often involve harsh reaction conditions, limited scalability, and poor atom economy. In this study, we report the development of a continuous flow process for the synthesis of N-substituted pyrroles using a solid acid catalyst, Amberlyst-15, under mild conditions. The reaction between primary amines and 1,4-dicarbonyl compounds was carried out in a tubular flow reactor, optimizing parameters including temperature, flow rate, and catalyst bed composition. The process demonstrated high yields (80–92%) and excellent reproducibility with minimal catalyst degradation after 20 cycles. This study highlights the advantages of flow chemistry and solid-supported catalysis in organic process intensification.