91勛圖

Peng Loh Y

Section on Cellular Neurobiology, Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute on Child Health and Human Development, National Institutes of Health, USA

Biography

Dr. Y. Peng Loh is the head of the Section on Cellular Neurobiology, Division on Molecular and Cellular Biology, NICHD. She and her group study the cell biology of endocrine and neuroendocrine cells, focusing on the mechanisms of biosynthesis and intracellular trafficking of peptide hormones and neuropeptides and their processing enzymes, the regulation of dense-core secretory granule biogenesis, and physiological roles of the prohormone processing enzyme carboxypeptidase E  (CPE) and its isoforms, and peptides derived from the neuroendocrine protein, chromogranin A.

Publications

Carbamazepine Prevents Hippocampal Neurodegeneration in Mice Lacking the Neuroprotective Protein, Carboxypetidase E

Carboxypeptidase E (CPE) has recently been described as a neuroprotective protein, and in mice devoid of CPE, a complete loss of the hippocampal CA3 neurons is observed. The pattern of loss is characteristic of that caused by status epilepticus. We therefore set out to determine when this loss occurred, what might induce it and if it could be preve... Read More»

Alicja Woronowicz, Niamh X Cawley and Peng Loh Y

Research Article: Clin Pharmacol Biopharm 2013, S1: 002

DOI:

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF